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Research results have been blended, some saying Lysine is helpful in decreasing and therapeutic cold sores, other research saying that it doesn't actually reduce the recurrence or severity of chilly sore outbreaks. Those included: lysine methylations on the C-terminus of the sequence or detected in peptides with acidic residues (potential artifacts of methyl esterification of the carboxylic group) and peptides with deamidation on the C-terminal arginine (tryptic cleavage after a deamidated residue have been lately proven as a highly unlikely event 41 ).
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